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Introduction : We have developed a database containing destabilizing regions in protein structures.  There is a strong correlation of destabilizing regions with protein function, inasmuch as this function is not related to conformational change.

Project : The students will take a database of protein-protein binding (BENCHMARK 4.0) and correlate the binding residues to our database of destabilizing regions (DESITE) as well as to hotspot regions of protein binding, to be identified using public domain software.

Requirements : Working knowledge of protein structure; solid knowledge of programming; basic knowledge of statistics; working knowledge of linux systems.